Vaccine adjuvant squalene, is it safe for elderly patients?

Hypodermic Syringe


The non-profit National Vaccine Information Center (NVIC) is questioning the basis for the fast tracked licensure by the U.S. Food and Drug Administration (FDA) of a squalene-adjuvanted influenza vaccine for use in seniors over age 65.

If the pharmaceutical corporations are doing this in the United States then they are or are going to do the same in Britain and across Europe, again, and give the same poison to the pensioners in their annual flu shot.

The Novartis MF59 adjuvanted Fluad vaccine was approved for accelerated licensure by the FDA Vaccines and Related Biological Products Advisory Committee (VRBPAC) on Sept. 15, 2015 primarily using limited immunogenicity and safety evidence from a small clinical trial in which only about 1,000 healthy Americans over age 65 were given the adjuvanted vaccine.[A][B]

Novartis failed to demonstrate that squalene adjuvanted Fluad was more effective or safer than an unadjuvanted influenza vaccine in the small clinical trial being used to justify accelerated licensure.

In fact, Fluad was shown to be far more reactive and, in some studies, the vaccine was associated with even more serious reactions in the elderly when given a second time, said NVIC Co-founder and President Barbara Loe Fisher.
What is a vaccination and how does it work?
The presumed intent of a vaccination is to help you build immunity to potentially harmful organisms that cause illness and disease. However, your body’s immune system is already designed to do this in response to organisms which invade your body naturally.

Most disease-causing organisms enter your body through the mucous membranes of your nose, mouth, pulmonary system or your digestive tract not through an injection.

These mucous membranes have their own immune system, called the IgA immune system. It is a different system from the one activated when a vaccine is injected into your body.

Your IgA immune system is your body’s first line of defence. Its job is to fight off invading organisms at their entry points, reducing or even eliminating the need for activation of your body’s immune system.
When a virus is injected into your body in a vaccine, and especially when combined with an immune adjuvant like squalene, your IgA immune system is bypassed and your body’s immune system kicks into high gear in response to the vaccination.

Injecting organisms into your body to provoke immunity is contrary to nature, and vaccination carries enormous potential to do serious damage to your health.

[Squalene is used in Chiron’s MF59 adjuvant, and Glaxo’s Monophosphoryl lipid A (MPL) and is the main factor in Gulf War Syndrome through the Anthrax vaccine.  Now they want to poison everyone with squalene in the Swine flu vaccine.]

3, is the number of diseases that squalene has caused in animals: Adjuvant Arthritis, Experimental Allergic Encephalomyelitis (EAE) and Systemic Lupus Erythematosus.Gary Matsumoto
See : Gary Matsumoto

Pandemrix (GlaxoSmithKline)
Squalene Citations
[2002 pdf] Antibodies to Squalene in Recipients of Anthrax Vaccine  Adjuvant disease has been shown to have a latency of onset in humans ranging from 2 weeks to 18 years after exposure (Brawer, 1996).

[2009 oct] Belgian doctors call for sack of government virologist in row over swine flu adjuvant advice The Belgian association of doctors has called for the government’s inter ministerial commissioner for the flu, the virologist Marc Van Ranst, to be fired after he said on Thursday that the Pandemrix swine flu jab with the adjuvant squalene was safe for pregnant women.
[2009 Aug] What’s the Danger of Swine Flu Vaccinations? by Dr. Anders Bruun Laursen
[Swine flu vax 2009 Aug] Injecting one thing for testing and then adding adjuvant later
[2009 Aug] H1N1 weapon of mass destruction vaccine and human experimentation
[2009] GSK admits in FEB 2009 that it planned on introducing squalene adjuvant ASO3 into regular season flu shots and aware of autoimmune issues!
[2009 July] Squalene: The Swine Flu Vaccine’s Dirty Little Secret Exposed By Dr. Mercola  A novel feature of the two H1N1 vaccines being developed by companies Novartis and GlaxoSmithKline is the addition of squalene-containing adjuvants to boost immunogenicity and dramatically reduce the amount of viral antigen needed.

[2006] Formation of Cysts from Squalene Adjuvant?
[Media Oct 2004] Castle insists on response from military, Pentagon asserts vaccine program safe to continue
[2005] A Glimpse into the Scary World of Vaccine Adjuvants By Edda West
Dr. Robert Garry Testimony, The House Subcommittee on National Security, Veterans Affairs, and International Relations
[Media July 2001] Illegal vaccine link to Gulf war syndrome
Breakthrough on Gulf War Illness By Paul M. Rodriguez
Gulf War Illness Update By Paul M. Rodriguez
Gulf War Mystery and HIV By Paul M. Rodriguez
The Gulf War Mystery By Paul M. Rodriguez
Holmdahl R, Lorentzen JC, Lu S, Olofsson P, Wester L, Holmberg J, Pettersson U. Arthritis induced in rats with nonimmunogenic adjuvants as models for rheumatoid arthritis. Immunol Rev. 2001 Dec;184:184-202. PMID: 12086312 [PubMed – in process]

Rat models are useful for studies of the pathogenesis of rheumatoid arthritis (RA) since rats are extraordinarily sensitive to induction of arthritis with adjuvants. Injection of not only the classical complete Freund’s adjuvant but also mineral oil without mycobacteria and pure adjuvants such as pristine and squalene, induce severe arthritis in many rat strains. Models like pristane-induced arthritis in rats are optimal models for RA since they fulfil the RA criteria including a chronic relapsing disease course. Arthritogenic adjuvants like pristane, avridine, squalene and mineral oil are not immunogenic since they do not contain major histocompatibility complex (MHC) binding peptides. Nevertheless, the diseases are MHC-associated and dependent on the activation of alphabetaTCR (T-cell receptor)-expressing T cells.

However, it has not been possible to link the immune response to joint antigens or other endogenous components although immunisation with various cartilage proteins induce arthritis but with different pathogeneses. To unravel the mechanisms behind adjuvant-induced arthritis, a disease-oriented genetic approach is optimal. Several loci that control onset of arthritis, severity and chronicity of the disease have been identified in genetic crosses and most of these have been confirmed in congenic strains. In addition, many of these loci are found in other autoimmune models in the rat as well as associated with arthritis in mice and humans.

(American Journal of Pathology. 2000;156:2057-2065.) 2000 American Society for Investigative Pathology The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats, Barbro C. Carlson*, …sa M. Jansson*, Anders Larsson , Anders Bucht * and Johnny C. Lorentzen* , From the Department of Medicine,*Unit of Rheumatology, Karolinska Institutet, Stockholm; the Department of Medical Sciences, University Hospital, Uppsala; and the Department of Biomedicine, Division of NBC Defense, Defense Research Establishment, Um, Sweden

Our results strongly suggest that the production of anti-squalene antibodies is linked to symptoms of Gulf War illness and to the presence of squalene found in certain lots of anthrax vaccine..human exposure to squalene in vaccines has been shown by others to cause immunological symptoms similar to those found in Gulf War illness patients. The absence of an association between the presence of Gulf War illness and deployment indicates that the causative agent or factor is not associated with the Persian Gulf. Consistent with this observation are the results of a recent epidemiological study finding that vaccinations that were given to both deployed and non-deployed personnel are associated with ill health.The presence of anti-squalene antibodies in ill people and the absence of the antibodies in healthy people is the first hard laboratory evidence that Gulf War illness is what some might refer to as a real disease. Dr. Robert Garry

GSK’s proprietary adjuvant is called ASO4. It contains alum and MPL. MPL stands for monophosphoryl lipid A. The U.S. Army’s proprietary (unlicensed) adjuvant developed prior to the first Gulf War for use in a second generation anthrax vaccine was called Tri-Mix or Triple Mix. Tri-Mix contained MPL (monophosphoryl lipid A) and squalene. After the war, Army scientists considered MPL to be too toxic, so they began working with Chiron Corporation of Emeryville, CA to develop an adjuvant that contained squalene and water only on the assumption that adjuvant toxicity with Tri-Mix was due to MPL. This assumption also proved incorrect. There are more than two dozen animal studies that generated data demonstrating squalene’s ability to induce autoimmunity; and there is disputed evidence that nano doses of squalene in anthrax vaccine sickened countless military personnel who received squalene-tainted vaccine during AVIP.  

Back to ASO4 and MPL. MPL was also a component of the Ribi Adjuvant System ( I haven’t checked whether it still is). The Ribi Adjuvant System, or RAS, is a derivative of Tri-Mix, which is approved for use in animals only.   

As far as I know, there is no existing data showing whether MPL elicits an immune response specific to it. If MPL is immunogenic, it raises the possibility of a dangerous cross reaction. The human body is full of lipids. Antibodies and immune cells responding to MPL might also respond to other lipids in the body, thus breaking tolerance for endogenous lipids (those native to the human body) and initiating autoimmunity. Secret adjuvant in new avian flu vaccine

Gulf War Correlation 
In science, a correlation does not prove causation. A correlation, however, is grounds to investigate causation, which has led to some troubling data. After the first Gulf War, many U.S. and British military personnel said they became sick after receiving anthrax immunisations. Scientists at Tulane University Medical School developed an assay showing a correlation between illness and antibodies to squalene. Although this data did not prove conclusively that Gulf War troops were injected with squalene, the data indicated that injection was the only way to develop these antibodies; the implication being that troops had been injected with a squalene-based adjuvant. 

U.S. Soldiers Wounded In Iraq And Afghanistan Diagnosed With TBI

This coincided with the fact that at the time, U.S. Army scientists had developed several new and theoretically improved anthrax vaccines that provided more immunity than the licensed vaccine; and did so in less time and with fewer shots. All these new anthrax vaccines contained squalene. I interviewed dozens of Gulf War veterans whose mysterious undiagnosable illnesses were later diagnosed by civilian physicians as autoimmune. Of the sick Gulf War veterans tested by Tulane’s scientists, 95% had antibodies to squalene.

Tulane’s data showed another correlation, and this one concerned them even more. Veterans who never deployed to the Gulf had developed chronic and debilitating illnesses too 100% of sick,non-deployed veterans tested by Tulane had anti-squalene antibodies. When Tulane tested healthy veterans, they found that 0% had the antibodies; that’s zero percent.

[2006] Formation of Cysts from Squalene Adjuvant?

In 1998, active duty military personnel deploying to an AOR (Area of Responsibility), which included Saudi Arabia and South Korea, were injected with anthrax vaccine. Many personnel reported sickness after their immunisations, which were later determined by FDA testing to contain trace quantities of squalene. The Department of Defense and the FDA stated that these quantities were too small to harm anyone and that the nanogram quantities of squalene in the vaccine probably came from the eggs in which germs for vaccines are grown.

There was a problem with this explanation. Viruses are grown in eggs; bacteria are not. Anthrax is a bacteria. Then the DOD and FDA suggested the squalene came from the bacteria itself. However, scientists had analysed Bacillus anthracis and proven that it does not produce squalene. DOD then offered a third explanation: the oils in human skin contain squalene; someones hands must’ve contaminated the vaccine. The problem with that explanation was that vaccine workers wear gloves and hats and booties.

The other problem is that oil and water don’t mix. Nevertheless, trace quantities of squalene had been emulsified in millions of vaccine doses. It wasn’t found smeared on the exterior of glass ware. It was in the vaccine. Special detergents must be added to an oil to break it down sufficiently to mix it with water. What DOD and the FDA left out of their explanations was this. In 1998, the DOD, FDA and NIH formed a Special Working Group to accelerate the development of the Army’s new anthrax vaccine containing squalene. Also that year, NIH scientists published data, which indicated, they said, that animals can become tolerated to squalene with micro-dosages. Coincidentally, nanogram doses of squalene, parts per billion, appeared in the military’s anthrax vaccine supply that same year, in 1998.

[2006] Formation of Cysts from Squalene Adjuvant?

Military personnel injected with anthrax vaccine containing squalene have been reporting that they developed cysts, appearing all over their bodies. Among the first to report this were Air Force personnel at Dover Air Force Based in Delaware, which had received at least four lots of anthrax vaccine containing squalene. One fellow developed cysts all over his body, including his pericardium. Another fellow developed them on his spinal cord. These cysts were similar to those in British civilians injected with the flu vaccine containing mineral oil, because they were sterile they were not associated with viral or bacterial infection.

[2006] Formation of Cysts from Squalene Adjuvant?

Two Last Correlations
Department of Defense and Health and Human Services regulations permit the administration of experimental drugs and vaccines to U.S. military personnel without informed consent. In contravention of the principles memorialised in the Nuremberg Code, the administration of Investigational New Drugs (INDs) can be done covertly, in clinical trials that are classified. This is stated in unclassified documents issued by the Department of Defense and Department of Health and Human Services. [2006] Formation of Cysts from Squalene Adjuvant? Since the early 1950s, U.S. military scientists working in cooperation with scientists with the NIH, FDA, and U.S. Public Health Service have been testing cyst-producing oil-based vaccine adjuvants on U.S. military personnel.

[2006] Formation of Cysts from Squalene Adjuvant?

I discuss the British findings, briefly, in Chapter Twelve, pg 250. A highly regarded British laboratory, Scientific Analyses Ltd. (SAL Ltd.) in Manchester, tested samples of British-made anthrax vaccine for the Granada Television network and found a thirty-six parts per billion concentration of squalene in two lots of the British vaccine. That is a fairly close match for the concentration found in one of the five lots confirmed by the U.S. Food and Drug Administration to contain squalene. Lot #FAV 043, according to the FDA, contained forty parts per billion.

What is also noteworthy is the specific test used by SAL Ltd. to detect squalene in anthrax vaccine: flame ionisation/gas chromatography. This is the same test used by the FDA. Interestingly, a laboratory the U.S. Army sub-contracted to test the vaccine, SRI, used a much less sensitive analysis called liquid chromatography, which would have been incapable of finding squalene in the concentrations present in either the U.S. or British anthrax vaccines. SRI has a long business association with the Department of Defense and an unanswered question is whether SRI deliberately chose to use a test that would invariably fail to find low concentrations squalene in the vaccine and thus allow the U.S. Department of Defense to declare its anthrax vaccine squalene-free, which it did.

Gary Matsumoto

According to the World Intellectual Property Organisation, which is part of the United Nations, scientists from the organisation are developing vaccines specifically to damage fertility as a method of contraception. A suggested ingredient for the vaccine is tween 80 (polysorbate 80) :

In a preferred embodiment the vaccine comprises oil, preferably a biodegradable oil such as squalene oil. Typically, the vaccine is prepared using an adjuvant concentrate which contains lecithin in squalene oil. The aqueous solution glycoprotein is typically a phosphate-buffered saline (PBS) solution, and additionally preferably contains Tween 80.

(Fertility Impairing Vaccine And Methods of Use This application claims the benefit of U. S. Provisional Application No. 60/070,375, filed January 2,1998, U. S. Provisional Application No. 60/071,406, filed January 15,1998.)

Exploring Vaccines
Vaccine A: The Covert Government Experiment That’s Killing Our Soldiers and Why GIs Are Only the First Victims By Gary Matsumoto

1. Many new vaccines feature recombinant DNA. One piece of a deadly germ is inserted or spliced into other organisms, creating bio-engineered microbial molecules. To prompt the body to create antibodies to these recombinants, scientists have created deadly oil-based vaccine additives called adjuvants. Oil-based adjuvants cause extreme inflammation and animals injected with them always develop painful, incurable auto-immune diseases like multiple sclerosis, rheumatoid arthritis or systemic lupus.

2.  Since Gulf War I, the military has been secretly putting an oil-based adjuvant called squalene into certain experimental lots of military vaccines. Just like lab animals, thousands of soldiers given squalene- laced vaccines have developed disabling auto-immune diseases. Independent researchers have found squalene antibodies in these sick soldiers. In 2005, the military admitted that 1,200 military personnel who received anthrax vaccine before going to Iraq recently developed serious illnesses, including memory loss and chronic fatigue.

3. The military and federal health agencies have long kept their squalene experiments on U.S. military troops secret because they know that oil-based adjuvants wreak havoc with immune function, causing the body to attack itself. Matsumoto documents how federal and military officials have often been caught lying about the Squalene in military vaccines. 

4.Matsumoto warns that the National Institutes of Health has funded production of new vaccines for flu, human papilloma virus, malaria, HIV and herpes that also contain squalene. The federal government has been running human clinical tests on these new commercial vaccines and test subjects have not been properly informed of the grave health dangers. Researchers have even found squalene in some of the older vaccines containing tetanus and diphtheria toxoids. Should we wonder why auto-immune diseases like fibromyalgia and chronic fatigue are now rampant? 

5.The Bush administration is funding development of new bio-warfare vaccines that will also contain oil- based squalene adjuvants like MF59 or MPL. Because federal officials know that these vaccines may cause disability or death, legislation to protect vaccine makers from lawsuits is expected to be passed by Congress before the end of 2005.* If you become chronically ill from these vaccines, tough luck!  Exploring Vaccines

Our demonstration that an auto-adjuvant can trigger chronic, immune-mediated joint-specific inflammation may give clues to the pathogenesis of rheumatoid arthritis, and it raises new questions concerning the role of endogenous molecules with adjuvant properties in chronic inflammatory diseases.

The Endogenous Adjuvant Squalene Can Induce a Chronic T-Cell-Mediated Arthritis in Rats

What Does the Institute of Medicine Have to Say?
The Institute of Medicine has concluded that the egg (ovalbumin) present in current vaccines causes the development of egg allergy in non-allergic people.
Adding an adjuvant (MF59) to an egg containing vaccine will cause more people to develop severe egg allergies.

Vaccine trials do not look for development of allergies.

Adverse events on our list thought to be due to IgE-mediated hypersensitivity reactions
Antigens in the vaccines that the committee is charged with reviewing do not typically elicit an immediate hypersensitivity reaction (e.g., hepatitis B surface antigen, toxoids, gelatine, ovalbumin, casamino acids). However, as will be discussed in subsequent chapters, the above-mentioned antigens do occasionally induce IgE-mediated sensitisation in some individuals and subsequent hypersensitivity
reactions, including anaphylaxis.
Document Pg. 65 (pdf pg. 94 )

[A] FDA. Briefing Document: Influenza Vaccine, Adjuvanted Fluad, Novartis Vaccines and Diagnostics, Inc, Applicant.
[B]Novartis. FDA Advisory Committee Briefing Document: Fluad, Seasonal Adjuvanted Trivalent Influenza Vaccine (aTIV.)

Further Study
WHO Memos 1972 Explains How to Turn Vaccines into a Means of Killing
Cancer Epidemic Due To The Introduction Of Viruses Through Vaccinations, SV-40 On Trial

Tags : Allergic Encephalomyelitis, Anthrax Vaccine, Arthritis, Chiron’s MF59, Digestive Tract, Glaxo’s Monophosphoryl lipid A (MPL), Gulf War Syndrome, IgA Immune System, Mucous Membranes, Pulmonary System, Rheumatoid Arthritis, Squalene, Flu Vaccine, Systemic Lupus Erythematosus